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The standard reference for nomenclature and diagnostic criteria in toxicologic pathology.

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Background: Standardization

The goal of scientists working in the field of toxicologic pathology is since many years the harmonization of nomenclature and diagnostic criteria for lesions observed in laboratory rats and mice. Initiatives had been started in the late 80s in the United States by the STP (Society of Toxicologic Pathology) and in Europe by the RITA data base group (Registry of Industrial Toxicology Animal-data).

Both initiatives resulted in internationally recognized publications:

In the mid 90th the "Joint STPs/ILSI Committee on International Harmonization of Nomenclature and Diagnostic Criteria in Toxicologic Pathology" was established with the objective to coordinate the international activities for the standardization of diagnostic criteria of proliferate lesions in mice and to reconciliate the already published nomenclature of proliferative lesions in rats. Consequently, the "Rat Nomenclature Reconciliation Subcommittee" was formed during the Annual STP meeting 1998 in Vancouver with the goal to eliminate discrepancies existing between the published nomenclature systems and to reach a common consensus. The results were published in 2000 in the Internet:

An electronic version of the RITA/WHO/IARC developments and publications - the Registry Nomenclature Information system (RENI) - is available since 1989 for members of the RITA project.

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